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  • Title: Synthesis and cytotoxicity of novel fatty acid-nucleoside conjugates.
    Author: Zhang YX, Dai GF, Wang L, Tao JC.
    Journal: Bioorg Med Chem Lett; 2007 Mar 15; 17(6):1613-5. PubMed ID: 17239599.
    Abstract:
    N(3)-Hydroxyethyltegafur (3) was synthesized in 91.0% yield under a new condition. A series of novel fatty acid esters of 3 were synthesized. These fatty acid-nucleoside conjugates have shown cytotoxicities against Ec9706 cells and A549 cells, and the structure activity relationship was discussed.
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