These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Trypanosoma congolense infections: MHC class II-restricted immune responses mediate either protection or disease, depending on IL-10 function.
    Author: Shi MQ, Wei GJ, Tabel H.
    Journal: Parasite Immunol; 2007 Feb; 29(2):107-11. PubMed ID: 17241399.
    Abstract:
    BALB/c mice are highly susceptible and C57BL/6 relatively resistant to Trypanosoma congolense infections. Here we show that relatively resistant wild-type B6 mice infected with T. congolense survive significantly longer (> 200 days) than infected major histocompatibility complex (MHC) class II-deficient B6 mice (approximately 50 days). We also show that blocking of the interleukin-10 (IL-10) receptor induces early death of wild-type B6 mice infected with T. congolense (approximately 10 days), but does not affect the survival of infected MHC class II-deficient B6 mice. We conclude that MHC class II-restricted immune responses mediate protection and, when IL-10 function is impaired, MHC class II-restricted immune responses mediate early mortality in otherwise resistant B6 mice. Thus, in T. congolense infections, MHC class II-restricted immune responses mediate either protection or disease, depending on IL-10 function.
    [Abstract] [Full Text] [Related] [New Search]