These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Peritumoral edema after stereotactic radiosurgery for intracranial meningiomas and molecular factors that predict its development.
    Author: Kan P, Liu JK, Wendland MM, Shrieve D, Jensen RL.
    Journal: J Neurooncol; 2007 May; 83(1):33-8. PubMed ID: 17245625.
    Abstract:
    INTRODUCTION: Stereotactic radiosurgery (SRS) is an effective treatment for small and medium-sized meningiomas. Although uncommon, peritumoral edema can develop as a delayed complication after SRS. The purpose of the study was to evaluate the clinical and molecular risk factors for peritumoral edema after SRS for intracranial meningiomas. METHODS: We retrospectively reviewed the results from 18 patients with intracranial meningiomas who underwent SRS. Tissue was obtained from 14 of these patients who also underwent surgery (13 before SRS). Peritumoral edema, before and after SRS, was estimated using the edema index. Quantitative differences in molecular markers of angiogenesis (VEGF, VRGFr) and hypoxia (HIF-1, GLUT-1, and CA-IX) as well as proliferative indices between patients with and without an elevated edema index after SRS were evaluated. RESULTS: Of the 18 patients studied, symptomatic peritumoral edema developed in three after SRS. They were treated with steroids and one required surgical intervention. The mean time to edema onset was 5.5 months, with an average duration of 16 months. Sagittal sinus occlusion and high-grade histology appear to be more common in the edema group. VEGF and HIF-1 were found in tumors with higher edema index and the elevation of these proteins was correlated with peritumoral edema after SRS. Proliferative index was not predictive for peritumoral edema. CONCLUSION: Clinical characteristics and molecular markers may identify patients with meningiomas at risk of peritumoral edema after SRS. Judicious use of steroids or perhaps the use of stereotactic fractionated radiation should be considered in these high-risk patients.
    [Abstract] [Full Text] [Related] [New Search]