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  • Title: Septamycin, a polyether antibiotic. Taxonomy, fermentation, isolation and characterization.
    Author: Keller-Juslén C, King HD, Kis ZL, von Wartburg A.
    Journal: J Antibiot (Tokyo); 1975 Nov; 28(11):854-9. PubMed ID: 172482.
    Abstract:
    Septamycin is a metal complexing polyether antibiotic produced by a strain of Streptomyces hygroscopicus NRRL 5678. The metabolite, a monocarboxylic acid, was isolated as the sodium salt C48H81NaO16. The crystal structure and absolute configuration were established by X-ray analysis of the p-bromophenacyl derivative. Septamycin has a thirty-carbon backbone and contains seven heterocyclic rings. Supported by direct comparison septamycin proved to be identical with antibiotic A28695 A isolated from Streptomyces albus NRRL 3883. The metabolite is active against gram-positive bacteria and Eimeria tenella (chicken coccidiosis).
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