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  • Title: Treatment of idiopathic hypereosinophilic syndrome with imatinib mesylate.
    Author: Garg A, Duggal L, Aggarwal S, Jain N.
    Journal: J Assoc Physicians India; 2006 Nov; 54():883-6. PubMed ID: 17249259.
    Abstract:
    Patients with idiopathic hypereosinophilic syndrome (HES) show persistent hypereosinophilia of unknown etiology that is associated with end-organ damage. Different treatments, including the use of corticosteroids and cytotoxics, have been investigated for HES with modest success. We report a young patient with HES who developed stroke and remained refractory to conventional therapy. Therapy with imatinib mesylate, a selective tyrosine kinase inhibitor that is highly effective in treating patients with BCR-ABL-positive chronic myeloid leukemia, was tried with the patient. The result was impressive, with hematologic remission achieved rapidly. Our finding concurs with recent reports that imatinib mesylate may be a promising agent in the treatment of some cases of HES.
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