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  • Title: Activation of the central cholinergic pathway increases post-exercise tail heat loss in rats.
    Author: Prímola-Gomes TN, Pires W, Rodrigues LO, Coimbra CC, Marubayashi U, Lima NR.
    Journal: Neurosci Lett; 2007 Feb 08; 413(1):1-5. PubMed ID: 17250962.
    Abstract:
    The aim of this study was to evaluate the effects of stimulation of the central cholinergic pathway on the regulation of post-exercise tail heat loss in rats. Either 2.0microL of 25x10(-3)M physostigmine (Phy) or 0.15M NaCl solution (Sal) were injected into the right lateral cerebral ventricle of both resting (n=8) and post-exercising rats (n=6; 24mmin(-1); 25min; 5% inclination). Tail temperature (Ttail) was measured using a thermistor taped to the tail, and intraperitoneal temperature, an index of core temperature (Tc), was recorded using a telemetry sensor implanted into the peritoneal cavity. In resting rats, Phy induced an increase in both Ttail (26.8+/-0.3 degrees C Phy versus 25.2+/-0.6 degrees C Sal; P<0.05) and in heat loss index (0.26+/-0.03 Phy versus 0.14+/-0.05 Sal; P<0.05; 30min after injection), and a decrease in Tc compared to the Sal injection group (36.6+/-0.2 degrees C Phy versus 37.0+/-0.2 degrees C Sal; P<0.05). In post-exercising rats, Phy injection attenuated the decrease in both T(tail) (28.3+/-0.8 degrees C Phy versus 26.4+/-0.6 degrees C Sal; P<0.05) and heat loss index (0.37+/-0.07 Phy versus 0.19+/-0.02 Sal; P<0.05) without altering Tc. We conclude that activation of the central cholinergic pathway increases post-exercise tail heat loss in rats.
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