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  • Title: [Pharmacodynamics of allapinine during long-term infusion in patients with chronic ischemic heart disease and frequent ventricular extrasystole].
    Author: Khakimov AG, Merkulova IN, Semeĭkin OV, Frolova EP, Mansurova GL, Mazaev AV, Ruda MIa.
    Journal: Kardiologiia; 1991 Nov; 31(11):58-62. PubMed ID: 1725191.
    Abstract:
    During a prolonged (24-hour) intravenous administration in a dose of 126 mg, allapinine produced a stable pronounced antiarrhythmic effect in 90% of the patients with frequent premature ventricular contraction and adverse reactions in the central nervous system in 65% of the cases. However, the latter effect of allapinine is short-term and ceased independently without altering the infusion rate. More serious adverse effects (hypotensive reactions, proarhythmic effects) occurred in 4% of the cases.
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