These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Kavain inhibits non-stereospecifically veratridine-activated Na+ channels.
    Author: Gleitz J, Gottner N, Ameri A, Peters T.
    Journal: Planta Med; 1996 Dec; 62(6):580-1. PubMed ID: 17252507.
    Abstract:
    The action of the natural kava pyrone, (+)-kavain, and its synthetic racemate, (+/-)-kavain, on voltage-dependent Na+ channels was investigated, while considering their stereospecific properties, on veratridine-induced increases in cytosolic free Na+ and Ca2+ ([Na+]i, [Ca2+]i) and the release of endogenous glutamate from cerebrocortical synaptosomes. Both compounds dose-dependently suppressed the veratridine-induced increase in [Na+]i, [Ca2+]i and glutamate release with IC50 values (+/- S.D.) of 71 +/- 22, 72 +/- 7, 120 +/- 37 micromol/l (+)-kavain and 77 +/- 21, 90 +/- 14, 92 +/- 23 micromol/l (+/-)-kavain, respectively. As judged from the dose-dependency, IC50 values, velocity and time course of action, both kava pyrones were equally effective suggesting a non-stereospecific inhibition of veratridine-activated Na+ channels.
    [Abstract] [Full Text] [Related] [New Search]