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  • Title: Significance of human T-lymphotropic virus type I indeterminant serological findings among healthy individuals.
    Author: Lipka JJ, Young KK, Kwok SY, Reyes GR, Sninsky JJ, Foung SK.
    Journal: Vox Sang; 1991; 61(3):171-6. PubMed ID: 1725466.
    Abstract:
    Follow-up studies on 67 blood donors with indeterminant serological findings for human T-lymphotropic virus (HTLV) type I by standard immunoassays showed no evidence of infection by polymerase chain reaction analysis for HTLV-I or HTLV-II nucleic acids or by antibody reactivity to a unique HTLV-I recombinant envelope protein, MTA-4. Among HTLV-I- or -II-infected individuals, a history of blood transfusion, past residence in established HTLV-I endemic areas or some association with intravenous drug use were common. In contrast, 85% of indeterminant cases had none of these risk factors. These observations suggest that healthy individuals with indeterminant serology for HTLV-I should not require additional studies.
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