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  • Title: [Effects of morphine on cutaneous blood flow and substance P release evoked by electric stimulation of rat sciatic nerve].
    Author: Chen JQ, Yonehara N, Imai Y, Xu WJ, Inoki R.
    Journal: Zhongguo Yao Li Xue Bao; 1991 Jul; 12(4):355-7. PubMed ID: 1725470.
    Abstract:
    Electric stimulation of the rat sciatic nerve containing sensory afferent fibers produced an increase in cutaneous blood flow. Morphine (10, 30 mumol.kg-1 ia infusion) inhibited the electric stimulation-induced increase of the cutaneous blood flow velocity, and its effect was antagonized by naloxone (2 mg.kg-1 ip). In order to investigate the cause of this effect, we determined immunoreactive substance P (iSP) levels in the sc perfusate of hind paw. We found that electric stimulation of the sciatic nerve led to a significant increase of iSP release into the sc perfusate. Morphine (30 mumol.kg-1 ia infusion) inhibited the electrical stimulation-induced release of iSP, and this effect was completely antagonized by naloxone (2 mg.kg-1 ip). These result suggest that morphine-induced inhibition of the electrical stimulation-evoked increase in cutaneous blood flow could result from inhibition of the release of SP from peripheral sensory nerve endings.
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