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  • Title: Extracellular phospholipase A2 and histamine release from rat peritoneal mast cells.
    Author: Nagai H, Sakamoto T, Kondo M, Miura T, Inagaki N, Koda A.
    Journal: Int Arch Allergy Appl Immunol; 1991; 96(4):311-6. PubMed ID: 1725674.
    Abstract:
    Phospholipase A2 (PLA2) from cobra (Naja naja) venom and PLA2 from porcine pancreas accelerated IgE antibody-mediated histamine release from rat peritoneal mast cells. These enhancements were clearly abrogated by heating the enzymes and pretreatment with parabromophenacyl bromide, mepacrine and antiflammin. Indomethacin (cyclooxygenase inhibitor) and AA-861 (lipoxygenase inhibitor) did not affect the enhancement by PLA2. These results indicate that extracellular PLA2 enhances the IgE antibody-mediated histamine release from rat peritoneal mast cells without the participation of arachidonate.
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