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  • Title: Catalytic multicomponent reactions for the synthesis of N-aryl trisubstituted pyrroles.
    Author: Galliford CV, Scheidt KA.
    Journal: J Org Chem; 2007 Mar 02; 72(5):1811-3. PubMed ID: 17256992.
    Abstract:
    Dirhodium(II) salts efficiently catalyze the three-component assembly reaction of an imine, diazoacetonitrile (DAN), and an activated alkynyl coupling partner to form substituted 1,2-diarylpyrroles in moderate to good yields. The transition-metal-catalyzed decomposition of the diazo compound in the presence of the imine presumably generates a transient azomethine ylide that undergoes cycloaddition with dipolarophiles in a highly convergent manner.
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