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  • Title: Renal effects of nitrendipine.
    Author: Ruilope LM.
    Journal: J Cardiovasc Pharmacol; 1991; 18 Suppl 5():S10-3. PubMed ID: 1725795.
    Abstract:
    Calcium-entry blockers exert several characteristic effects on the kidney that potentiate their antihypertensive effect. Long-term therapy with nitrendipine, a dihydropyridine derivative, lowers blood pressure while maintaining renal hemodynamics within limits similar to pretreatment values in essential hypertension with normal renal function. This is accompanied by a persistent natriuretic effect that probably facilitates its antihypertensive action and is not followed by changes of the renin-angiotensin-aldosterone system. Preliminary data also seem to indicate that nitrendipine could be safely used in patients with arterial hypertension and chronic renal failure.
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