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  • Title: [Clinical study of levonorgestrel-releasing intrauterine system for adenomyosis].
    Author: He SM, Zhang YD.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2006 Dec; 26(12):1794-6. PubMed ID: 17259122.
    Abstract:
    OBJECTIVE: To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis. METHODS: Seventy patients with adenomyosis diagnosed according to clinical symptoms, magnetic resonance imaging (MRI) findings, laparoscopy and/or color-Doppler ultrasound imaging were treated with LNG-IUS, and the menstrual blood volume, dysmenorrhea, uterine volume, hepatic function and serum lipids were observed and evaluated. RESULTS: In the first month of treatment, the menstrual blood size was reduced significantly to (35-/+12)% of that before treatment (P<0.01), and further to (7-/+4)% in the twelfth month (P<0.01). The average uterine volume was decreased by 18.6% (P<0.05) after the treatment, and dysmenorrhea was obviously relieved or completely disappeared alleviated. The condition of anemia was also improved rapidly, and no obvious side-effects on hepatic function and serum lipids were observed. CONCLUSION: LNG-IUS is an effective and safe therapy for adenomyosis.
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