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  • Title: Substance P-immunoreactive innervation from the retina to the suprachiasmatic nucleus in the rat.
    Author: Takatsuji K, Miguel-Hidalgo JJ, Tohyama M.
    Journal: Brain Res; 1991 Dec 24; 568(1-2):223-9. PubMed ID: 1726067.
    Abstract:
    The present study examined substance P (SP) innervation in the suprachiasmatic nucleus (SCN) of the rat. In the colchicine-untreated rat, SP-immunoreactive fibers formed a dense oval plexus in the ventral part of the SCN. After bilateral eye enucleation, there was a marked reduction in SP-immunoreactive fibers in the ventral part of the SCNs. The SP-immunoreactive neurons in the retinal ganglion cell layer were retrogradely labeled after injection of Fluoro-gold into the SCN. These findings indicate the presence of the SP innervation from the retina to the SCN in the rat. The role of SP in the retino-hypothalamic tract was discussed from the light-dark cycle.
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