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  • Title: Chlorahololides A and B, two potent and selective blockers of the potassium channel isolated from Chloranthus holostegius.
    Author: Yang SP, Gao ZB, Wang FD, Liao SG, Chen HD, Zhang CR, Hu GY, Yue JM.
    Journal: Org Lett; 2007 Mar 01; 9(5):903-6. PubMed ID: 17263543.
    Abstract:
    [structure: see text] Chlorahololides A(1) and B(2), two highly complex sesquiterpenoid dimers, were isolated from Chloranthus holostegius. Their structures and absolute configurations were established by NMR spectroscopy, X-ray crystallography, and CD. Chlorahololides A (1) and B (2) exhibited potent and selective inhibition on the delayed rectifier (IK) K+ current, with an IC50 of 10.9 and 18.6 microM, respectively.
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