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  • Title: [Determination of elastase and alpha 2-macroglobulin in bronchoalveolar lavage fluid in patients with interstitial diseases and its clinical significance].
    Author: Li ZH.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 1991 Dec; 14(6):333-5, 375-6. PubMed ID: 1726366.
    Abstract:
    Determination of elastase and its inhibitor alpha 2-Macroglobulin was done in BALF in 40 patients with ILD (study group) and 10 healthy volunteers (control group). The results showed that BALF levels of elastase and alpha 2-macroglobulin in study group were significantly higher than those in control group (P less than 0.01; P less than 0.05). Correlation was found between BALF elastase levels and cell count (r = 0.3214, P less than 0.05). It was suggested that elastase may play a role in the development of pulmonary fibrosis in interstitial lung diseases.
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