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  • Title: The influence of histamine on metabolism of dopamine and serotonin in the rat striatum.
    Author: Nowak JZ.
    Journal: Acta Physiol Pol; 1977; 28(2):101-5. PubMed ID: 17265.
    Abstract:
    The influence of histamine on metabolism of dopamine and serotonin in the rat striatum. Acta Physiol. Pol., 1977, 28 (2): 101--105. Histamine-2HC1 (Hi) given in a dose of 500 micron g did not change DA level in the striatum but HVA was increased by approx. 50%. The Hi-induced rise of HVA level was prevented in animals pretreated with an antihistaminic drug--mepyramine. The pretreatment of rats with atropine reduced significantly the Hi-induced rise of HVA concentration. Hi did not significantly influence 5-HT content in the striatum while the level of 5-HIAA was simultaneously increased by 15%. It is concluded that Hi-induced elevation of HVA content is not a direct effect of Hi on dopaminergic neurons but the Hi action is exerted indirectly through cholinergic system. The increase of serotoninergic activity is probably a consequence of an increased activity of dopaminergic neurons in the striatum.
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