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  • Title: Synthetic oligonucleotides for biomedical applications.
    Author: Seliger H, Fröhlich A, Gröger G, Krist B, Montenarh M, Rösch H, Rösch R, Ortigao FR.
    Journal: Nucleic Acids Symp Ser; 1991; (24):193-6. PubMed ID: 1726743.
    Abstract:
    New developments of oligonucleotides for biomedical applications are surveyed. Diagnostic probes were conveniently labelled by enzymatic immunogenic tailing with 5-bromo-deoxyuridine triphosphate. "Antisense" oligonucleotides of potential therapeutic value were stabilized against nucleolytic decay by inversion of terminal internucleotidic linkages. Introduction of 2'-deoxy-2'-fluoro-nucleotide units enhances duplex stability and conveys resistance to ribonucleases.
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