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  • Title: Pyruvate kinase deficiency complicating pregnancy.
    Author: Wax JR, Pinette MG, Cartin A, Blackstone J.
    Journal: Obstet Gynecol; 2007 Feb; 109(2 Pt2):553-5. PubMed ID: 17267892.
    Abstract:
    BACKGROUND: Pyruvate kinase deficiency is the second-most common hereditary nonspherocytic hemolytic anemia. Only four affected patients' pregnancies have been reported since 1980. CASES: A 22-year-old without prior splenectomy experienced severe hemolytic anemia, with hematocrit as low as 19.0%, requiring serial transfusions. She developed preeclampsia at term and was delivered by cesarean for a nonreassuring fetal heart rate. Another patient with a splenectomy experienced chronic low-grade hemolysis, with the hematocrit ranging from 26.4-31.6%, not requiring transfusion. She delivered vaginally at term after labor induction for fetal growth restriction. CONCLUSION: Despite contrasting maternal courses, preeclampsia, nonreassuring fetal heart rate patterns, and fetal growth restriction, pyruvate kinase deficiency is associated with good maternal-fetal outcomes.
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