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  • Title: Successful treatment of dermatomyositis during pregnancy with intravenous immunoglobulin monotherapy.
    Author: Williams L, Chang PY, Park E, Gorson KC, Bayer-Zwirello L.
    Journal: Obstet Gynecol; 2007 Feb; 109(2 Pt2):561-3. PubMed ID: 17267895.
    Abstract:
    BACKGROUND: Dermatomyositis is rare during pregnancy and, if untreated, is associated with poor fetal outcome. Corticosteroids are a standard treatment for dermatomyositis in pregnancy, but they have adverse effects. Intravenous immune globulin is an effective therapy for this condition and may have few adverse effects. CASE: A young, white primigravida presented with dermatomyositis at 4 5/7 weeks of gestation (creatine kinase 2,762 units/L). Intravenous immune globulin was administered monthly at a dose of 1 g/(kg.d) for 2 consecutive days. The patient's symptoms resolved and no complications were experienced during therapy. At term, creatine kinase was 29 units/L and a healthy 3,657.5-g (8-lb, 1-oz) neonate was born. CONCLUSION: Pregnant patients with dermatomyositis can be treated with intravenous immune globulin, resulting in good fetal outcome, thus avoiding the deleterious effects of corticosteroid therapy on pregnancy.
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