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  • Title: Various signal molecules modulate voltage-activated ion currents on snail neurons.
    Author: Szücs A, Stefano GB, Hughes TK, Rózsa KS.
    Journal: Acta Biochim Biophys Hung; ; 26(1-4):139-43. PubMed ID: 1726948.
    Abstract:
    The modulatory effects of interleukin-1 (IL-1), an immunotransmitter, and FMRFamide, a molluscan neuropeptide, were studied on identified neurons of Helix pomatia L. (Mollusca, Gastropoda) by using the method of two microelectrode voltage clamp. IL-1 and FMRFamide uniformly decreased the voltage-activated inward current (ICa), while the voltage-dependent outward potassium current (Inet K) increased. IL-1 and FMRFamide were shown to use the same cellular targets as used by the low molecular weight neurotransmitters.
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