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  • Title: HIV, HBV and HCV seropositivity in hemophiliacs.
    Author: Chow MP, Lin CK, Lin JS, Chau WK, Ho CH, Chen SY, Lee SH, Yung CH.
    Journal: Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi; 1991 Nov; 24(4):339-44. PubMed ID: 1726973.
    Abstract:
    Eleven cases of severe type hemophiliacs who had received long-term factor VIII injections were tested for the serological markers of human immunodeficiency virus (HIV), hepatitis B virus and hepatitis C virus (HCV). The period of factor VIII concentrate injections ranged from 2 to 32 years. The seropositive rates of HIV and HCV were 9/11(82%) and 11/11(100%), respectively. The seropositive rate of hepatitis B surface antigen was only 1/11(9%), while the seropositive rates of antibody to hepatitis B core antigen and antibody to hepatitis B surface antigen were 9/11(82%) and 7/11(64%), respectively, Although the patients had no symptoms related to acquired immunodeficiency syndrome, they were noted to have inverted helper/suppressor T-lymphocyte ratio, suggesting that hemophiliacs with long-term factor VIII injections have a high incidence of HIV and HCV infection, with immunological aberration.
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