These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Author: Wang K, Li J, Degterev A, Hsu E, Yuan J, Yuan C. Journal: Bioorg Med Chem Lett; 2007 Mar 01; 17(5):1455-65. PubMed ID: 17270434. Abstract: Necrostatin-5 (Nec-5) is a novel potent small-molecule inhibitor of necroptosis structurally distinct from previously described Necrostatin-1 (Nec-1), and therefore, represents a new direction for the inhibition of this cellular caspase-independent necrotic cell death mechanism. Here, we describe a series of structural modifications of Nec-5 and the structure-activity relationship (SAR) of Nec-5 series in inhibiting necroptosis.[Abstract] [Full Text] [Related] [New Search]