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  • Title: Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5.
    Author: Wang K, Li J, Degterev A, Hsu E, Yuan J, Yuan C.
    Journal: Bioorg Med Chem Lett; 2007 Mar 01; 17(5):1455-65. PubMed ID: 17270434.
    Abstract:
    Necrostatin-5 (Nec-5) is a novel potent small-molecule inhibitor of necroptosis structurally distinct from previously described Necrostatin-1 (Nec-1), and therefore, represents a new direction for the inhibition of this cellular caspase-independent necrotic cell death mechanism. Here, we describe a series of structural modifications of Nec-5 and the structure-activity relationship (SAR) of Nec-5 series in inhibiting necroptosis.
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