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  • Title: Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase.
    Author: Cateni F, Bonivento P, Procida G, Zacchigna M, Scialino G, Banfi E.
    Journal: Bioorg Med Chem Lett; 2007 Apr 01; 17(7):1971-8. PubMed ID: 17270436.
    Abstract:
    Monoglucosyl and monogalactosyl diglycerides (MGDGs) with medium-long length acyl chains, identified as active components in Euphorbiaceae, were synthesized. They were examined for antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. MGDGs with two octanoyl groups at both 1- and 2-positions showed the most potent activity. The stereoselectivity of pancreatic lipase was investigated in vitro where the preference for the 1 position in MGDGs is strictly related to the length of the acyl chains.
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