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  • Title: Macrophage inflammatory protein-1alpha: a link between innate immunity and familial Mediterranean fever?
    Author: Dizdar O, Kalyoncu U, Karadag O, Akdogan A, Kiraz S, Ertenli I, Barista I, Calguneri M.
    Journal: Cytokine; 2007 Jan; 37(1):92-5. PubMed ID: 17270460.
    Abstract:
    The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha (MIP-1alpha) were assessed in the patients and the controls, along with other parameters of disease activity, i.e., fibrinogen, C-reactive protein and erythrocyte sedimentation rate. Serum MIP-1alpha levels of the patients with FMF in acute attack period were significantly higher than the patients in remission and healthy controls (p=0.02 and p=0.038, respectively). MIP-1alpha levels were weakly correlated with CRP (r=0.32, p=0.032) levels. MIP-1alpha may have a role in the pathogenesis of FMF attacks. MIP-1alpha and other chemokines may constitute a link between the innate immune system and FMF.
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