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  • Title: Effects of L-NMMA and L-NNA on the selective ATP-induced enhancement of intratumoral blood flow.
    Author: Natori Y, Moriguchi M, Fujiwara S, Takeshita I, Fukui M, Iwaki T, Kanaide H.
    Journal: J Cereb Blood Flow Metab; 1992 Jan; 12(1):120-7. PubMed ID: 1727133.
    Abstract:
    We studied the effects of NG-monomethyl-L-arginine (L-NMMA) and N omega-nitro-L-arginine (L-NNA) on the selective ATP and adenosine-induced enhancement of intratumoral blood flow in rats measured by the hydrogen clearance method. Both adenosine and ATP produced a selective enhancement of the intratumoral blood flow. Neither L-NMMA nor L-NNA had a significant effect on either the CBF or the intratumoral blood flow. Adenosine-induced enhancement was not inhibited by L-NMMA or L-NNA. On the other hand, the ATP-induced enhancement was totally inhibited by both L-NMMA and L-NNA. The inhibitory action of L-NMMA against ATP was blocked by L-arginine, but not by D-arginine. It is suggested that the ATP-induced increase of intratumoral blood flow is evoked by nitric oxide synthesized from the endothelium of the intratumoral blood vessels.
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