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  • Title: Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives.
    Author: Bi Y, Xu J, Wu X, Ye W, Yuan S, Zhang L.
    Journal: Bioorg Med Chem Lett; 2007 Mar 01; 17(5):1475-8. PubMed ID: 17275295.
    Abstract:
    New 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives were prepared and tested for cytotoxic activity on five cancer cell lines in vitro: all tested compounds showed stronger cytotoxic activity than 23-hydroxy betulinic acid and betulinic acid. In addition, compound 5a was tested for anti-tumor activity in vivo: it had much better anti-tumor activity than 23-OH betulinic acid and had similar anti-tumor activity with cyclophosphamide and 5-fluorouracil.
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