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  • Title: Synthesis and biological evaluation of unprecedented classes of spiro-beta-lactams and azido-beta-lactams as acyl-CoA:cholesterol acyltransferase inhibitors.
    Author: Benfatti F, Cardillo G, Gentilucci L, Tolomelli A.
    Journal: Bioorg Med Chem Lett; 2007 Apr 01; 17(7):1946-50. PubMed ID: 17275297.
    Abstract:
    Unprecedented classes of four- and five-membered hydroxyl-spiro-beta-lactams and hydroxyl-azido-beta-lactams were prepared via regioselective ring opening of hydroxyl-epoxides. The potential of these particular beta-lactams as biologically active compounds has been confirmed by the results obtained in ACAT inhibition assays.
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