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  • Title: Treatment of extensive cutaneous metastatic melanoma with topical diphencyprone.
    Author: Damian DL, Thompson JF.
    Journal: J Am Acad Dermatol; 2007 May; 56(5):869-71. PubMed ID: 17276544.
    Abstract:
    Diphencyprone is a potent contact sensitizer sometimes used to treat alopecia areata and cutaneous warts. A patient with previous primary nodular melanoma on the scalp developed extensive, confluent cutaneous metastases near the primary site, unsuitable for treatment with surgery or radiotherapy. Topical treatment with diphencyprone as a single agent resulted in regression of all lesions, and the patient remains well 18 months later. Topical immunotherapy with diphencyprone was an inexpensive and well-tolerated treatment for extensive cutaneous melanoma metastases in our patient unsuitable for other therapies.
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