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  • Title: Chemistry and biology of resorcylic acid lactones.
    Author: Winssinger N, Barluenga S.
    Journal: Chem Commun (Camb); 2007 Jan 07; (1):22-36. PubMed ID: 17279252.
    Abstract:
    While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.
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