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  • Title: Lipoprotein receptors and genetic control of cholesterol metabolism in cultured human cells.
    Author: Brown MS, Goldstein JL.
    Journal: Naturwissenschaften; 1975 Aug; 62(8):385-9. PubMed ID: 172803.
    Abstract:
    Biochemical analysis of cultured fibroblasts obtained from human subjects with the autosomal dominant disorder familial hypercholesterolemia has led to the identification of a hitherto unrecognized cell-surface receptor for serum lipoproteins. This receptor plays a critical role in the physiologic regulation of cholesterol metabolism in human cells, and its absence leads to elevation of serum-cholesterol levels and severe atheroslerosis.
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