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  • Title: Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients.
    Author: Dubovsky SL, Murphy J, Thomas M, Rademacher J.
    Journal: Am J Psychiatry; 1992 Jan; 149(1):118-20. PubMed ID: 1728159.
    Abstract:
    The authors measured intracellular Ca2+ concentrations in four manic and five bipolar depressed patients and seven comparison subjects. Platelet and lymphocyte intracellular Ca2+ concentrations were comparable. The patients' mean intracellular Ca2+ concentrations were higher than those of the comparison subjects and demonstrated more interindividual variation. These findings suggest a diffuse abnormality in mechanisms affecting intracellular calcium homeostasis in bipolar disorder.
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