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  • Title: HLA-DRB1*03 is a susceptibility gene in patients with Graves' disease with and without ophthalmopathy.
    Author: Yarman S, Oguz F, Carin M.
    Journal: Int J Immunogenet; 2007 Feb; 34(1):23-5. PubMed ID: 17284224.
    Abstract:
    We sought an association between certain human leucocyte antigen (HLA) markers and Graves' disease (GD) with and without ophthalmopathy (OP). One hundred and thirty-one Turkish patients with GD (50 without OP, 81 with OP) and 250 local healthy controls were studied. HLA-DRB1 typing was performed by using polymerase chain reaction-sequence-specific primers (PCR-SSP) method. The frequencies of DRB1*03 was significantly increased in GD compared to controls (OR = 2.07; 95% CI = 1.24-3.44), whereas DRB1*13 (OR = 0.33; 95% CI = 0.18-0.61) and DRB1*07 (OR = 0.31; 95% CI = 0.13-0.70) were significantly increased in controls compared to patients. None of the three associations showed any specificity to the OP group.
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