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  • Title: Diverse sugar-binding specificities of marine invertebrate C-type lectins.
    Author: Matsubara H, Nakamura-Tsuruta S, Hirabayashi J, Jimbo M, Kamiya H, Ogawa T, Muramoto K.
    Journal: Biosci Biotechnol Biochem; 2007 Feb; 71(2):513-9. PubMed ID: 17284851.
    Abstract:
    The sugar-binding specificities of C-type lectins isolated from marine invertebrates were investigated by frontal affinity chromatography (FAC) using 100 oligosaccharides. The lectins included BRA-2 and BRA-3, multiple lectins from the hemolymph of the acorn barnacle, Megabalanus rosa, and BRL from the acorn barnacle, Balanus rostatus. The diverse sugar-binding specificities of the C-type lectins were determined by FAC analysis. BRA-2 recognized alpha2-6 sialylation but not alpha2-3 sialylation on glycans. On the other hand, BRA-3 showed high affinity for oligosaccharides with alpha-linked non-reducing terminal galactose, but not for sialylated forms, and BRL showed enhanced recognition activity towards Lewis(x) and Lewis(a) epitopes.
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