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  • Title: [Epileptogenic activity of tripeptide corticotropin-releasing factor fragment (CRF(4-6))].
    Author: Makarenko EIu, Berdiev RK, Andreeva LA, Mart'ianov AA.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 2006; 56(6):788-95. PubMed ID: 17285774.
    Abstract:
    The effects of centrally administered tripeptide fragment CRF(4-6) of corticotropin-releasing factor on convulsive activity in outbred albino rats were investigated. The peptide CRF(4-6) (icv; 6, 30, 150 nmol/head) causes dose-dependent increase in total EEG power in 1-40 Hz frequency range as a reflection of tripeptide-induced various epileptiform EEG signs such as single peaks and spike trains without external convulsion. Higher doses of CRF(4-6) (icv; 150, 225, 300 nmol per animal) induce tonicoclonic seizures. Switching to convulsive activity occurs at CRF(4-6) dose of 150 nmol per animal: injection of this dose leads only to EEG paroxysmal activity under habitual conditions and induces pathological locomotor activation under stressing conditions. Thus, CRF(4-6) similarly to full-length corticotropin-releasing factor induces epileptiform activity in rats.
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