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  • Title: Safety factor for neuromuscular transmission at type-identified diaphragm fibers.
    Author: Ermilov LG, Mantilla CB, Rowley KL, Sieck GC.
    Journal: Muscle Nerve; 2007 Jun; 35(6):800-3. PubMed ID: 17286272.
    Abstract:
    The safety factor (SF) for neuromuscular transmission varies across limb muscles of different fiber-type composition. Using intracellular recordings in rat diaphragm fibers, we found that SF varies across muscle fiber types (even within a single muscle), being larger for type IIx or IIb fibers than for type I or IIa fibers. Fiber-type differences in activation history or mechanical load may contribute to differences in SF and are important determinants of neuromuscular plasticity.
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