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  • Title: Duplicated sequence motif in the long terminal repeat of maedi-visna virus extends cell tropism and is associated with neurovirulence.
    Author: Oskarsson T, Hreggvidsdóttir HS, Agnarsdóttir G, Matthíasdóttir S, Ogmundsdóttir MH, Jónsson SR, Georgsson G, Ingvarsson S, Andrésson OS, Andrésdóttir V.
    Journal: J Virol; 2007 Apr; 81(8):4052-7. PubMed ID: 17287273.
    Abstract:
    Maedi-visna virus (MVV) is a lentivirus of sheep causing chronic inflammatory disease of the lungs (maedi) and the nervous system (visna). We have previously shown that a duplicated sequence in the long terminal repeat (LTR) of MVV is a determinant of cell tropism. Here, we demonstrate that deletion of a CAAAT sequence from either one of the repeats resulted in poor virus growth in sheep choroid plexus cells. A duplication in the LTR encompassing the CAAAT sequence was found in four neurological field cases that were sequenced, but no duplication was present in the LTRs from seven maedi cases; one maedi isolate was mixed. These results indicate that the duplication in the LTR is associated with neurovirulence.
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