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  • Title: Highly enantioselective Michael addition of aromatic ketones to nitroolefins promoted by chiral bifunctional primary amine-thiourea catalysts based on saccharides.
    Author: Liu K, Cui HF, Nie J, Dong KY, Li XJ, Ma JA.
    Journal: Org Lett; 2007 Mar 01; 9(5):923-5. PubMed ID: 17288432.
    Abstract:
    [reaction: see text] A new class of thiourea catalysts have been developed which integrate saccharide and primary amine moieties into one small organic molecule. These simple catalysts are shown to be highly enantioselective for direct Michael addition of aromatic ketones to a range of nitroolefins (up to 98% ee).
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