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  • Title: [Cutaneous manifestations of paraproteinemia and their mechanisms].
    Author: Lipsker D, Boeckler P.
    Journal: Presse Med; 2007; 36(7-8):1135-40. PubMed ID: 17289338.
    Abstract:
    Disease entities characterized by the presence of paraproteins have a variety of cutaneous manifestations. These manifestations may be classified in the following categories as a function of their mechanisms: * extracutaneous deposition of paraproteins, as in amyloidosis * intravascular paraprotein deposition, as in cryoglobulinemia * cutaneous lesions resulting from the biologic activity of paraprotein, as in patients with normolipemic xanthoma with monoclonal immunoglobulin anti-LDL activity * abnormal cytokine secretion, as in AESOP (adenopathy and extensive skin patch overlying a plasmacytoma) or POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) syndromes * unknown mechanisms.
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