These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Tuning bulk electrostatics to regulate protein function.
    Author: Serber Z, Ferrell JE.
    Journal: Cell; 2007 Feb 09; 128(3):441-4. PubMed ID: 17289565.
    Abstract:
    Cyclin-dependent kinase activation can prevent yeast cells from responding to mating pheromone. Strickfaden et al. (2007) now show that this block arises from the multisite phosphorylation of Ste5. This provides a beautiful example of how phosphorylation can produce decisive changes in protein function through bulk electrostatics, without the necessity of intricate conformational changes.
    [Abstract] [Full Text] [Related] [New Search]