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  • Title: Thermolabile T (tumor) antigen from cells transformed by a temperature-sensitive mutant of simian virus 40.
    Author: Tenen DG, Baygell P, Livingston DM.
    Journal: Proc Natl Acad Sci U S A; 1975 Nov; 72(11):4351-5. PubMed ID: 172906.
    Abstract:
    Partially purified tumor (T) antigen from a strain of Chinese hamster lung cells transformed by wild-type simian virus 40 (SV 40) and either of two temperature-sensitive SV 40 mutants has been studied as a DNA binding protein. The DNA binding activity present in the T-antigen-containing fractions is inhibited by purified hamster anti-T IgG but not by equivalent amounts of nonimmune hamster IgG. T from either wild-type- or tsC219-transformed cells is relatively stable during heating at 44 degrees compared to T prepared from tsA239-transformed cells. These results strongly suggest that T is a product of the SV 40 A gene.
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