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  • Title: [Fish meat retarding the progression of chronic renal failure in spontaneously hypercholesterolemic rats].
    Author: Liang XM, Otani H.
    Journal: Wei Sheng Yan Jiu; 2006 Nov; 35(6):727-30. PubMed ID: 17290752.
    Abstract:
    OBJECTIVE: To investigate the effects of different dietary proteins of fish meat and casein upon the progression of chronic renal failure (CRF) in spontaneously hypercholesterolemic (SHC) rats. METHODS: 48 SHC rats of 10 weeks of age were randomly divided into four groups, and placed on diets containing 20% and 40% casein or fish protein respectively till they were 22 weeks of age. 24-hour urine collections were obtained along with measurements of systolic blood pressure and blood were drew from their tail vein evry 4 weeks. Finally, the kidneys were removed and prepared for histological and immunohistochemistry study . RESULTS: Fish meat diet slowed the progression of proteinuria, renal function failure and glomerular injury compared with the control casein diet in both 20% and 40% dietary groups. CONCLUSION: Fish meat retarded the progression of CRF in SHC rats compared with casein.
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