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  • Title: beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells.
    Author: Faraldo MM, Teulière J, Deugnier MA, Birchmeier W, Huelsken J, Thiery JP, Cano A, Glukhova MA.
    Journal: FEBS Lett; 2007 Mar 06; 581(5):831-6. PubMed ID: 17292359.
    Abstract:
    P-cadherin expression is restricted to the basal layer of stratified epithelia including that of the mammary gland. Although evidence for an important role of P-cadherin in mammary morphogenesis and tumorigenesis is increasing, the mechanisms that regulate its expression are poorly understood. We show that in basal mammary epithelial cells, beta-catenin is associated with the P-cadherin promoter and activates its expression independently of LEF/TCF in a cell-type specific manner. Down-regulation of endogenous beta-catenin levels by RNA interference technique inhibited P-cadherin promoter activity. In vivo, in skin and mammary gland of mutant mice, activation of beta-catenin signalling correlates with up-regulation of P-cadherin expression. These data suggest that beta-catenin-dependent modulation of P-cadherin expression can contribute to the establishment of the basal phenotype.
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