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  • Title: Effect of the anti-oxidant probucol on soluble thrombomodulin (sTM) in hypercholesterolemic rabbits.
    Author: Hong SC, Zhao SP, Liu Q, Wu ZH.
    Journal: Int J Cardiol; 2008 Jan 11; 123(2):180-2. PubMed ID: 17292497.
    Abstract:
    INTRODUCTION: Thrombomodulin is an integral endothelial cell membrane protein, exists not only on the surface of endothelial cells but also as soluble fragments circulating in plasma. Probucol has anti-oxidant properties as well as cholesterol-lowering effects and may affect soluble thrombomodulin (sTM). METHODS: Sixteen rabbits fed with high-cholesterol diet for 8 weeks were randomly divided into two groups: (1) high-cholesterol group (n=8): maintained high-cholesterol diet; (2) probucol group (n=8): the same diet plus probucol for 6 weeks. Control group (n=8) was fed with normal diet for 14 weeks. The levels of sTM and oxidized low-density lipoprotein (OX-LDL) were measured using ELISA. RESULTS: There were atherosclerotic lesions in aortas and intimal thickness significantly increased in high-cholesterol group. Probucol significantly reduced the lesion area (56.4%+/-9.8% vs 82.5%+/-10.5%) and decreased the intimal thickness (44.65+/-7.25 mum vs 72.21+/-8.32) as compared with high-cholesterol group, all P<0.01. Probucol decreased the level of OX-LDL and sTM as compared with high-cholesterol group, all P<0.05. CONCLUSIONS: Probucol retarded the plaques formation may relate to decrease plasma OX-LDL and sTM concentration, which may improve endothelial function in hypercholesterolemic rabbit.
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