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  • Title: Free interleukin-2 receptors in children with trisomy 21 (Down's syndrome) and different levels of periodontal disease.
    Author: Cutando-Soriano A, Gómez-Moreno G, Bravo M.
    Journal: Int J Paediatr Dent; 1998 Sep; 8(3):177-80. PubMed ID: 17294624.
    Abstract:
    AIMS: To investigate levels of free interleukin-2 (IL-2) receptors in relation to differing levels of CIPD in children with trisomy 21 (Down's syndrome). DESIGN: Cross-sectional study of soluble IL-2 receptors in serum samples. SAMPLE AND METHOD: Eighty children aged 10-13 years were included; 40 children with Down's syndrome and with varying levels of CIPD and 40 control children without Down's syndrome and without periodontitis. Serum samples were analysed using an enzyme-linked immunosorbent assay (ELISA) with two monoclonal antibodies. RESULTS: In children with Down's syndrome and periodontitis, serum IL-2 receptor levels were significantly higher than in control subjects.
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