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  • Title: [Action of corticotropin-releasing hormone on its own receptor type-1 in human placenta].
    Author: Wang XD, Yu HY, He MM, Liu SY.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2007 Jan; 38(1):101-4. PubMed ID: 17294739.
    Abstract:
    OBJECTIVE: To investigate the expression of corticotropin-releasing hormone and its receptor type-1 in human placental tissues during caesarian operations. METHODS: IHC-SP staining and ISH methods were adopted to identify the expression patterns of CRH and its receptor CRH-R1 in the placenta taken from the women who had uncomplicated pregnancies. The placental tissues were collected after caesarian operations on the women with threatened labor. RESULTS: Positive expressions of both CRH and CRH-R1 messenger ribonucleic acid and peptide were found in the placental tissues, but the later was stronger (P<0.05). CONCLUSION: The elevated level of placental CRH may be a trigger of the transcription of its own receptor CRH-R1 during caesarian operations. This positive feedback of CRH on its own receptor may represent a functional adaptation of human utero-plcental-fetal unit in responding to stress.
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