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  • Title: [Effect of dexamethasone on expression of intercellular adhesion molecule-1 in orbital fibroblasts from thyroid associated ophthalmopathy].
    Author: He WM, Luo QL, Zeng JH.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2007 Jan; 38(1):113-5. PubMed ID: 17294742.
    Abstract:
    OBJECTIVE: To investigate the effects of dexamethasone (DEX) on the expression of intercellular adhesion molecule-1 (ICAM-1) in orbital fibroblasts (OF) from patients with thyroid associated ophthalmopathy (TAO). METHODS: OFs from 10 patients with TAO and from 5 normal control subjects were cultured in vitro. OFs were incubated with DEX, IFN-gamma or DEX and IFN-gamma compound for 72 hours. Flow cytometry analyses were performed to determine ICAM-1 expression. RESULTS: Baral ICAM-1 expression in OFs from TAO was significantly higher than that in the controls. DEX (10(-6) mol/L) inhibited expression of ICAM-1. IFN-gamma (300 U/ mL) stimulated ICAM-1 expression significantly, which was inhibited by DEX (10(-6) mol/L). CONCLUSION: ICAM-1 plays an important role in the pathogenesis of TAO. DEX not only inhibits ICAM-1 expression, but also inhibits IFN-gamma-induced ICAM-1 expression on cultured OF in vitro. This may be part of the mechanism by which glucocorticoid has efficacy in the treatment of TAO.
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