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  • Title: Efficacy of alpha-lipoic acid against diabetic cataract in rat.
    Author: Kojima M, Sun L, Hata I, Sakamoto Y, Sasaki H, Sasaki K.
    Journal: Jpn J Ophthalmol; 2007; 51(1):10-3. PubMed ID: 17295134.
    Abstract:
    PURPOSE: alpha-Lipoic acid (LA) is well known as a powerful antioxidant. The efficacy of dihydrolipoate-LA for oral administration against streptozotocin (STZ)-induced diabetic cataract in rat was investigated. METHODS: Rats were divided into three groups, control, diabetes mellitus (DM), and DM treated with LA (DM+LA). Diabetes was induced by intravenous injection of 50 mg/kg STZ. DM+LA rats were fed 30 mg/rat per day LA in their diet. Lens changes were assessed using Scheimpflug images (EAS-1000) and by measuring light-scattering intensity. RESULTS: Increase in lens light scattering was less (P < 0.05) in DM+LA rats than in DM rats 5 weeks after induction of diabetes. DM rats had the highest and control rats the lowest blood glucose levels at every measurement point up to 111 days (P < 0.05). CONCLUSION: LA treatment delayed development and progression of cataract in rats with streptozotocin-induced diabetes.
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