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  • Title: Evaluation of anti-diarrhoeal and anti-ulcerogenic potential of ethanol extract of Carpolobia lutea leaves in rodents.
    Author: Nwafor PA, Bassey AI.
    Journal: J Ethnopharmacol; 2007 May 22; 111(3):619-24. PubMed ID: 17296280.
    Abstract:
    The effect of ethanol extract of Carpolobia lutea leaves on experimentally induced diarrhoea and ulcers was studied in rodents. The extract (245-735 mg/kg) inhibited small intestinal transit time (15.10-45.03%), castor oil-induced diarrhoea (25.69-43.54%) and fluid accumulation (7.53-34.15%), respectively, as well as indomethancin (47.64-79.79%) and ethanol-induced (65.63-89.65%) ulcer models. The various degrees of inhibitions were statistically significant (p < 0.001). The phytochemical screening confirmed the presence of tannins, saponins and flavonoids. Others include cardiac glycosides, anthraquinones and terpenes. The median lethal dose (LD50) was determined to be 2449.49 mg/kg body weight. Though the mechanism of action of the extract may not be fully understood, the extract may in part be mediating its actions through its inhibitory effects on alpha2-adrenoceptor and cholinergic (anti-muscarinic receptor) systems or through the actions of its active metabolites.
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